IMPLANTS STUDY ABOUT THE RELATIONSHIP BETWEEN MOZART SONATA K448 AND THE EXTINCTION OF FEAR´S MEMORY TO THE SOUND IN MALE MICETO THE SOUND IN MALE MICE
Keywords:
Memory, Extinction, MozartAbstract
Introduction: Memory is defined as the capacity a living being persue to capture, store and receive information. In a similar way, there are mechanisms capable of extinguishing them, through the depression of stimuli responsable for creating the memories. Considering that, some studies exist to corroborate the positive implications of classical music by Mozart in increasing hippocampal neurogenesis, however, there is still a gap that may establish this relationship in the extinction process. Objective: To investigate the interference of Mozart Sonata K448 in the memory of sound´s fear in male mice. Methodology: The project was performed with 22 C57BL/6 mice, as approved by the Ethics in Animal Use Committee, under protocol 08/21. They were divided in three groups: G1 – Mozart (n=12), G2 – Environment (n = 5) and G3 – Control (n=5). Only G1 was exposed to music, meanwhile G2/G3 were exposed only to ambient noise. From the 50th to the 53rd day, the animals were habituated. On the 54th, aversive training was performed with groups (G1/G2). On the 55th, the extinction test started, lasting 12 consecutive days. The procedures were recorded using the Etholog 2.22 software to analyze the behavior of the mice. Results: There was no significant difference between groups for an aversive training session (t(15)=2.02; p=0.062; the mean ± SEM of the percentage of freezing behavior for the Mozart group (0.86% ± 0.20%) was equal to that of the Environment group (0.19% ± 0.12%). Likewise, the main effect of the groups (F(2;19)=2.11; p=0.149) was not verified, as well as the interaction days*groups (F(10.54; 100.09)=1.24; p= 0.276). Conclusions: No significant difference was found between the group exposed to the Mozart Sonata and the environment group, with regard to the extinction of the traumatic memory after exposure to sound and shock. Also, it was possible to infer that exposure to Mozart did not produce negative effects on the consolidation or extinction of memory.
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